From Asheville
Take 1-40 West to US 74 West (Exit 27) and continue on to Bryson City Exit 67. One hour.

From Chattanooga
Take I-75 North to US 64 East to Murphy, NC. Then US 19/74 East to Bryson City Exit 67. Three hours.

From Knoxville (the scenic route)
Take I-40 East to TN 66 South (Exit 407) to US-441 South through Gatlinburg and the National Park to Cherokee. Then follow US-19 South to Bryson City. Three hours.

From Knoxville (via Interstate)
Take I-40 East into North Carolina to US 74 West (Exit 27) and continue on to Bryson City Exit 67. Two hours.

From West Atlanta
Take I-75 North to I-575 North to Blue Ridge, GA. Then GA 60 West to GA SPUR 60 to US-74 East (Murphy NC). Then US 19/74 East to Bryson City Exit 67. Three hours.

From East Atlanta
Take I-85 North to I-985, which becomes US 23, which becomes US 23/441. You’ll pass through Clayton, GA; Franklin, NC; and Dillsboro, NC. Just past Dillsboro, take US 74 West to Bryson City Exit 67. Three hours.